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Tag: asthma

Scientists track down a protein that may add to lung damage in asthma and related diseases

A step toward helping patients breathe deeply
A protein called TL1A drives fibrosis in several mouse models, making it harder for lungs and airways to function normally. Credit: La Jolla Institute for Immunology

Your lungs and airways need to be stretchy, sort of like balloons. Take a big breath, and they’ll open right up.

Damaged lungs can’t open properly. Patients with asthma, idiopathic pulmonary fibrosis and systemic sclerosis suffer from fibrosis and tissue remodeling, where a build-up of tissue and immune cells, and proteins that form a glue-like substance, keep the airways from expanding. As fibrosis gets worse, taking a breath feels like blowing up a balloon filled with concrete.

In a new study, researchers at La Jolla Institute for Immunology (LJI) report that a protein called TL1A drives fibrosis in several mouse models, triggering tissue remodeling, and making it harder for lungs and airways to function normally.

“Our new study suggests that TL1A and its receptor

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